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Article

Sirtuin Modulators: Mechanisms and Potential Clinical Implications

24 Apr 2012

Abstract excerpt

In the last years, studies about longevity have highlighted that caloric restriction can be linked with a less normal agingassociated damage, and in the same way, with the activity of the Silent Information Regulator 2 (SIR2) gene. Sir2-like genes, known as sirtuins (SIRTs), have been found in organisms ranging from bacteria to mammals promoting health and survival. At the moment, it has been identified seven...

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PMID: 22455589
DOI: 10.2174/092986712800269272

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