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Cellular and molecular biology of sirtuins in cardiovascular disease

30 May 2023

Abstract excerpt

Sirtuins (SIRTs) are a nicotinic adenine dinucleotide (+) -dependent histone deacetylase that regulates critical signaling pathways in prokaryotes and eukaryotes. Studies have identified seven mammalian homologs of the yeast SIRT silencing message regulator 2, namely, SIRT1-SIRT7. Recent in vivo and in vitro studies have successfully demonstrated the involvement of SIRTs in key pathways for cell biological...

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PMID: 37263163
DOI: 10.1016/j.biopha.2023.114931

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