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Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function

27 Mar 2019

Abstract excerpt

The rising incidence of type 2 diabetes mellitus (T2DM) is a major public health concern, and novel therapeutic strategies to prevent T2DM are urgently needed worldwide. Aging is recognized as one of the risk factors for metabolic impairments, including insulin resistance and T2DM. Inflammation, oxidative stress and mitochondrial dysfunction are closely related to both aging and metabolic disease. Calorie...

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PMID: 30972029
DOI: 10.3389/fendo.2019.00187

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