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Anti-tau single domain antibodies clear pathological tau and attenuate its toxicity and related functional defects

30 Jul 2024

Abstract excerpt

Tauopathies are a group of neurodegenerative diseases characterized by the presence of tau inclusions. We have developed over fifty anti-tau single-domain antibodies (sdAbs) derived from phage display libraries of a llama immunized with recombinant and pathological tau immunogens. We examined the therapeutic potential of four of these sdAbs in a Drosophila tauopathy model following their transgenic expression...

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PMID: 39079958
DOI: 10.1038/s41419-024-06927-9

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