Article
A mechanistic model of tau amyloid aggregation based on direct observation of oligomers.
Nature communications - 30 Apr 2015
Shammas Sarah L, Garcia Gonzalo A, Kumar Satish, Kjaergaard Magnus, Horrocks Mathew H, Shivji Nadia, Mandelkow Eva, Knowles Tuomas P J, Mandelkow Eckhard, Klenerman David
Abstract excerpt
Protein aggregation plays a key role in neurodegenerative disease, giving rise to small oligomers that may become cytotoxic to cells. The fundamental microscopic reactions taking place during aggregation, and their rate constants, have been difficult to determine due to lack of suitable methods to identify and follow the low concentration of oligomers over time. Here we use single-molecule fluorescence to study...
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