Article

A genetically encoded selection for amyloid-β oligomer binders

2025-03-11

Abstract excerpt

Soluble amyloid beta oligomers (AβOs) are a hypothesized source of neurotoxicity in Alzheimer’s Disease. Binding proteins that recognize these species may have high utility in diagnostic and therapeutic applications. However, identifying binders that recognize AβOs directly generated from the aggregation cascade is made challenging by the short lifetime and low concentrations of oligomer populations. We report a n...

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Literature Corpus work: b96d3616-3d47-57a9-8c4f-6905057eb413
DOI: 10.1101/2025.03.11.642651

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