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Article

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.

Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2013

Kondo Takeshi, Kobayashi Junya, Saitoh Tatsuya, Maruyama Kenta, Ishii Ken J, Barber Glen N, Komatsu Kenshi, Akira Shizuo, Kawai Taro

Abstract excerpt

Double-stranded DNA (dsDNA) derived from pathogen- or host-damaged cells triggers innate immune responses when exposed to cytoplasm. However, the machinery underlying the primary recognition of intracellular dsDNA is obscure. Here we show that the DNA damage sensor, meiotic recombination 11 homolog A (MRE11), serves as a cytosolic sensor for dsDNA. Cells with a mutation of MRE11 gene derived from a patient with...

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Source

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Identifiers

PMID: 23388631
DOI: 10.1073/pnas.1222694110
PMCID: PMC3581880

Genes

MRE11
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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