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Article

MRE11 as a molecular signature and therapeutic target for cancer treatment with radiotherapy

20 May 2021

Abstract excerpt

MRE11, the core of the MRE11/RAD50/NBS1 complex, is one of key DNA damage response proteins. Increasing evidence suggests that its expression in cancer cells is critical to developing radioresistance; as such, MRE11 is an emerging marker for targeted radiosensitization strategies. Elevated MRE11 in tumor tissues has been associated with poor survival in patients undergoing radiotherapy, although in some cancer...

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PMID: 34022282
DOI: 10.1016/j.canlet.2021.05.013

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