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Article

A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability.

Cell reports - 4 Feb 2020

Fagan-Solis Katerina D, Simpson Dennis A, Kumar Rashmi J, Martelotto Luciano G, Mose Lisle E, Rashid Naim U, Ho Alice Y, Powell Simon N, Wen Y Hannah, Parker Joel S, Reis-Filho Jorge S, Petrini John H J, Gupta Gaorav P

Abstract excerpt

The Mre11-Rad50-Nbs1 complex is a DNA double-strand break sensor that mediates a tumor-suppressive DNA damage response (DDR) in cells undergoing oncogenic stress, yet the mechanisms underlying this effect are poorly understood. Using a genetically inducible primary mammary epithelial cell model, we demonstrate that Mre11 suppresses proliferation and DNA damage induced by diverse oncogenic drivers through a...

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Identifiers

PMID: 32023457
DOI: 10.1016/j.celrep.2020.01.020
PMCID: PMC7361372

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