Article

A continuum reaction-diffusion model for spread of gene silencing in chromosomal inactivation

2025-06-04

Abstract excerpt

Regulation of gene silencing in large regions of chromosomes is crucial for development and disease progression, and there has been an increasing interest in using it for new therapeutics. One example of massive gene silencing is X chromosome inactivation (XCI), a process essential for dosage compensation of X-linked genes. During XCI, most genes in the X chromosome are inactivated following the transcription of X...

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Literature Corpus work: 6d89eee3-6e4a-58f0-8f25-c3d28b0b4f55
DOI: 10.1101/2025.06.02.657345

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