Article
Idiosyncratic evolvability among single-point ribosomal mutants towards multi-aminoglycoside resistance
2025-03-15
Abstract excerpt
Newly-arising mutations can impact not only fitness but also an organism’s capacity for further adaptation ( i.e. , its evolvability). Understanding what determines evolvability differences is of great interest from both fundamental and applied perspectives. A general pattern observed across multiple microbes is that evolvability tends to decline with genotype fitness ( i.e. , the "rule of declining adaptability...
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Identifiers and source
- Literature Corpus work
- 6d670072-d377-51ff-976f-501cffe67475
- DOI
- 10.1101/2025.03.13.643049