Article

Higher-order epistasis drives evolutionary unpredictability toward novel antibiotic resistance

2025-07-11

Abstract excerpt

<h4>ABSTRACT</h4> The rapid evolution of extended-spectrum β-lactamases (ESBLs) represents a global health threat, undermining the efficacy of β-lactams, the most extensively used antibiotic class. To elucidate the evolutionary dynamics underlying β-lactam resistance, we constructed a comprehensive combinatorial mutant library comprising all 55,296 possible TEM-1 β-lactamase variants integrating 18 clinically obs...

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Literature Corpus work: b63854ef-1c7d-5e79-86fe-f079a6ac7b82
DOI: 10.1101/2025.07.08.663783

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