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Article

Probing evolutionary repeatability: neutral and double changes and the predictability of evolutionary adaptation.

PloS one - 1 Jan 2009

Roy Scott William

Abstract excerpt

BACKGROUND: The question of how organisms adapt is among the most fundamental in evolutionary biology. Two recent studies investigated the evolution of Escherichia coli in response to challenge with the antibiotic cefotaxime. Studying five mutations in the beta-lactamase gene that together confer significant antibiotic resistance, the authors showed a complex fitness landscape that greatly constrained the...

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Identifiers

PMID: 19234610
DOI: 10.1371/journal.pone.0004500
PMCID: PMC2643001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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