Article
Evolvability as a function of purifying selection in TEM-1 β-lactamase.
Cell - 26 Feb 2015
Stiffler Michael A, Hekstra Doeke R, Ranganathan Rama
Abstract excerpt
Evolvability—the capacity to generate beneficial heritable variation—is a central property of biological systems. However, its origins and modulation by environmental factors have not been examined systematically. Here, we analyze the fitness effects of all single mutations in TEM-1 β-lactamase (4,997 variants) under selection for the wild-type function (ampicillin resistance) and for a new function (cefotaxime...
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