Determinants of Genetic Diversity of Spontaneous Drug Resistance in Bacteria.

doi:10.1534/genetics.115.185355

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Article

Determinants of Genetic Diversity of Spontaneous Drug Resistance in Bacteria.

Genetics - 1 Jul 2016

Couce Alejandro, Rodríguez-Rojas Alexandro, Blázquez Jesús

Abstract excerpt

Any pathogen population sufficiently large is expected to harbor spontaneous drug-resistant mutants, often responsible for disease relapse after antibiotic therapy. It is seldom appreciated, however, that while larger populations harbor more mutants, the abundance distribution of these mutants is...

Topics

Anti-Bacterial Agents
Biological Evolution
Drug Resistance, Bacterial
Genetic Variation
Genotype
Humans
Models, Genetic
Mutation
Neoplasms

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