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Germline Genetic Modulation of Systemic TROP2 Abundance: A Human Genetics–Guided Framework for Stratification of TROP2-Directed Antibody–Drug Conjugates

2026-05-29

Abstract excerpt

<title>Abstract</title> <p> Background Trophoblast cell-surface antigen 2 (TROP2; TACSTD2) is an important therapeutic target in epithelial malignancies and the target of multiple antibody–drug conjugates (ADCs). However, substantial interpatient variability in efficacy and dose-limiting toxicity remains incompletely understood. Current biomarker strategies rely primarily on tumor immunohistochemistry (IHC) and...

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Literature Corpus work: 6d18ad79-5712-5bbb-af92-8e97b449f8f8
DOI: 10.21203/rs.3.rs-9846882/v1

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