From amplicon to antigen: a quantified transmission map that nominates multi-antigen antibody–drug-conjugate co-target sets across cancer types

Abstract excerpt

Somatic copy-number amplification is pervasive in cancer, and the genes it carries are candidate drug targets—but only those whose amplification is transmitted to accessible surface protein can be reached by an antibody–drug conjugate (ADC). We build an integrated map of copy-number-to-protein transmission across six tumour types and ask, for every amplified gene, whether its dosage reaches the surface. Copy numbe...

Topics

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• Aged
• Antigens, Neoplasm
• CAR-T cell therapy research
• Immunotherapy, Adoptive
• Multiple Myeloma
• Multiple Myeloma Research and Treatments
• Mutation
• T-Lymphocytes

Identifiers and source

Literature Corpus work

64c252a1-e944-59ba-9273-4bd76e058a8a

DOI

10.64898/2026.07.13.26357987