Article

Genomic correlates of clinical CAR-T cell activity

2025-10-10

Abstract excerpt

<h4>ABSTRACT</h4> Chimeric antigen receptor (CAR)-T cell therapies demonstrate potent anti-tumor efficacy in hematologic malignancies, yet clinical outcomes remain unpredictable due to the bespoke nature of the treatment, which is manufactured from each patient’s own T-cells. While germline variants are known to influence response to immune checkpoint inhibitors 1, 2 , their role in CAR-T cell therapy is unknown....

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Literature Corpus work: 5d4ae689-404d-5b1a-ba58-8bd8d6d82cd9
DOI: 10.1101/2025.10.08.25337584

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