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Article

Genetic variation associated with thyroid autoimmunity shapes the systemic immune response to PD-1 checkpoint blockade.

Nature communications - 7 Jun 2021

Khan Zia, Hammer Christian, Carroll Jonathan, Di Nucci Flavia, Acosta Sergio Ley, Maiya Vidya, Bhangale Tushar, Hunkapiller Julie, Mellman Ira, Albert Matthew L, McCarthy Mark I, Chandler G Scott

Abstract excerpt

Activation of systemic immune responses using PD-1 checkpoint inhibitors is an essential approach to cancer therapy. Yet, the extent of benefit relative to risk of immune related adverse events (irAE) varies widely among patients. Here, we study endocrine irAE from 7 clinical trials across 6 cancers where atezolizumab (anti-PD-L1) was combined with chemotherapies and compared to standard of care. We show that...

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Share to Antibodies, Monoclonal, Humanized
Share to Autoimmunity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypothyroidism

Share to Immune Checkpoint Inhibitors

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Share to Thyroid Diseases

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Source

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Identifiers

PMID: 34099659
DOI: 10.1038/s41467-021-23661-4
PMCID: PMC8184890

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