Article

Multi-Omic Profiling Reveals Antibody-Drug Conjugate Targetability in Ovarian Cancer

2026-03-27

Abstract excerpt

Antibody-drug conjugates (ADCs) require high and homogeneous target expression for optimal efficacy, yet the spatial, temporal, and cellular heterogeneity of clinically approved ADC targets in high-grade serous ovarian cancer (HGSC) remains incompletely defined. We analyzed bulk RNA-sequencing, single-cell RNA-sequencing, and whole-genome sequencing data from 867 samples across 304 patients enrolled in the real-wo...

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Literature Corpus work: 11a8dc69-d1dd-50bd-8ffb-8eff4fc72441
DOI: 10.64898/2026.03.25.26349056

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