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The complex interplay of TROP2 and PD-L1 in immune regulation and drug resistance in lung cancer

1 Jan 2025

Abstract excerpt

The complex interplay of TROP2 and PD-L1 in lung adenocarcinoma (LUAD) influences drug resistance and immunotherapy efficacy remains incompletely understood yet.In this study, we investigated the relationship between TACSTD2 (encoding TROP2) and PD-L1 expression through transcriptome analysis, immunohistochemistry, and single-cell RNA sequencing in lung cancer cell lines, tumor tissues, and immune cells, focusing...

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PMID: 40520853
DOI: 10.62347/nhfj1535

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