Article

Alpaca Single B Cell Interrogation and Heavy-Chain-Only Antibody Discovery on an Optofluidic Platform

2023-02-12

Abstract excerpt

<h4>ABSTRACT</h4> In vivo discovery approaches for single domain antibodies such as VHH have been limited by the lack of methodologies available for camelid B cell interrogation. Here, we report a novel application of the Berkeley Lights Beacon® optofluidic platform to the discovery of heavy-chain-only antibodies by screening single B cells from alpacas immunized with two different targets. Custom methods for alp...

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Literature Corpus work: d969010a-09d6-5a0a-b640-a72bd3869c94
DOI: 10.1101/2023.02.10.528050

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