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Development, High-Throughput Profiling, and Biopanning of a Large Phage Display Single-Domain Antibody Library

27 Apr 2024

Abstract excerpt

Immunoglobulin G-based monoclonal antibodies (mAbs) have been effective in treating various diseases, but their large molecular size can limit their penetration of tissue and efficacy in multifactorial diseases, necessitating the exploration of alternative forms. In this study, we constructed a phage display library comprising single-domain antibodies (sdAbs; or “VHHs”), known for their small size and remarkable...

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Advanced Biosensing Techniques and Applications
Glycosylation and Glycoproteins Research
Monoclonal and Polyclonal Antibodies Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38732011
DOI: 10.3390/ijms25094791

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