Article

Maximum Antigen Diversification in a Lyme Bacterial Population and Evolutionary Strategies to Overcome Pathogen Diversity

2020-12-17

Abstract excerpt

Natural populations of microbes and their hosts are engaged in an arms race in which microbes diversify to escape host immunity while hosts evolve novel immunity. This co-evolutionary process, known as the “Red Queen” hypothesis, poses a fundamental challenge to the development of broadly effective vaccines and diagnostics against a diversifying pathogen. Based on surveys of natural allele frequencies and experime...

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Literature Corpus work: d4f75c52-e8e4-52a9-a2f4-ea86f90fe48d
DOI: 10.1101/2020.12.16.423180

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