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Article

Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain.

Nature communications - 13 Apr 2015

Pearce Margaret M P, Spartz Ellen J, Hong Weizhe, Luo Liqun, Kopito Ron R

Abstract excerpt

The brain has a limited capacity to self-protect against protein aggregate-associated pathology, and mounting evidence supports a role for phagocytic glia in this process. We have established a Drosophila model to investigate the role of phagocytic glia in clearance of neuronal mutant huntingtin (Htt) aggregates associated with Huntington disease. We find that glia regulate steady-state numbers of Htt aggregates...

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Identifiers

PMID: 25866135
DOI: 10.1038/ncomms7768
PMCID: PMC4515032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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