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Article

Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses.

eLife - 28 May 2020

Donnelly Kirby M, DeLorenzo Olivia R, Zaya Aprem DA, Pisano Gabrielle E, Thu Wint M, Luo Liqun, Kopito Ron R, Panning Pearce Margaret M

Abstract excerpt

Emerging evidence supports the hypothesis that pathogenic protein aggregates associated with neurodegenerative diseases spread from cell to cell through the brain in a manner akin to infectious prions. Here, we show that mutant huntingtin (mHtt) aggregates associated with Huntington disease transfer anterogradely from presynaptic to postsynaptic neurons in the adult Drosophila olfactory system. Trans-synaptic...

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Identifiers

PMID: 32463364
DOI: 10.7554/eLife.58499
PMCID: PMC7297539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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