Article

LC3-associated phagocytosis promotes glial degradation of axon debris after injury

2022-09-07

Abstract excerpt

<title>Abstract</title> <p>Glial engulfment of dead neurons and neurites after trauma, during development and in neurodegenerative diseases plays a crucial role in nervous system maintenance. Axon debris generated after traumatic injury is cleared by phagocytic glia via Draper receptor signalling in Drosophila. However, mechanisms governing the efficiency of axon debris phagocytosis and degradation have remained...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bdd18810-a7f4-5105-994a-a53f0059c636
DOI: 10.21203/rs.3.rs-2009846/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LC3-associated phagocytosis promotes glial degradation of axon debris after injuryDOI 10.21203/rs.3.rs-2009846/v1Read

Impairment of the glial phagolysosomal system drives prion-like propagation in a <i>Drosophila</i> model of Huntington’s diseaseSemantic proximity Read

Epidermal cells are the primary phagocytes in the fragmentation and clearance of degenerating dendrites in Drosophila.Semantic proximity Read

The autophagy protein Atg9 functions in glia and contributes to parkinsonian symptoms in a Drosophila model of Parkinson’s diseaseSemantic proximity Read

Sleep regulates the glial engulfment receptor Draper to promote Wallerian degenerationSemantic proximity Read

Glial Phagocytic Receptors Promote Neuronal Loss in Adult Drosophila BrainSemantic proximity Read

A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosisSemantic proximity Read

A Genome-wide CRISPR Screen Identifies WDFY3 as a Novel Regulator of Macrophage EfferocytosisSemantic proximity Read

Tweek-dependent formation of ER-PM contact sites enables astrocyte phagocytic function and remodeling of neuronsSemantic proximity Read

Adipocyte metabolic state regulates glial phagocytic functionSemantic proximity Read

Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCHSemantic proximity Read

MiR-223 Enhances Lipophagy by Suppressing CTSB in Microglia Following Lysolecithin-Induced Demyelination in MiceSemantic proximity Read

Orchestration of selective autophagy by cargo receptorsSemantic proximity Read