Article

Caught in the Act: targeted mutagenesis of the herpesvirus fusogen central helix captures transition states

2022-11-24

Abstract excerpt

Herpesviruses remain a burden for animal and human health, including the medically important varicella-zoster virus (VZV). Membrane fusion mediated by conserved core glycoproteins, the fusogen gB and the heterodimer gH-gL, enables herpesvirus cell entry. The ectodomain of gB orthologs has five domains and is proposed to transition from a prefusion to postfusion conformation but the functional relevance of the doma...

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Literature Corpus work: 6d02e964-ed53-5840-8d3e-2e5db2213159
DOI: 10.1101/2022.11.23.517751

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