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Article

Interplay between the Herpes Simplex Virus 1 gB Cytodomain and the gH Cytotail during Cell-Cell Fusion.

Journal of virology - 1 Dec 2015

Rogalin Henry B, Heldwein Ekaterina E

Abstract excerpt

UNLABELLED: Herpesvirus entry into cells is mediated by the viral fusogen gB, which is thought to refold from the prefusion to the postfusion form in a series of large conformational changes that energetically couple refolding to membrane fusion. In contrast to most viral fusogens, gB requires a conserved heterodimer, gH/gL, as well as other nonconserved proteins. In a further mechanistic twist, gB-mediated...

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Cell Fusion
CHO Cells
Cricetinae
Cricetulus
Herpesvirus 1, Human
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Structure, Tertiary

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Identifiers

PMID: 26401042
DOI: 10.1128/JVI.02391-15
PMCID: PMC4665236

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