Article
In Vitro Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry.
mBio - 4 May 2021
Vallbracht Melina, Lötzsch Henriette, Klupp Barbara G, Fuchs Walter, Vollmer Benjamin, Grünewald Kay, Backovic Marija, Rey Felix A, Mettenleiter Thomas C
Abstract excerpt
Herpesvirus entry and spread requires fusion of viral and host cell membranes, which is mediated by the conserved surface glycoprotein B (gB). Upon activation, gB undergoes a major conformational change and transits from a metastable prefusion to a stable postfusion conformation. Although gB is a structural homolog of low-pH-triggered class III fusogens, its fusion activity depends strictly on the presence of the...
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