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Article

Targeted mutagenesis of the herpesvirus fusogen central helix captures transition states.

Nature communications - 2 Dec 2023

Zhou Momei, Vollmer Benjamin, Machala Emily, Chen Muyuan, Grünewald Kay, Arvin Ann M, Chiu Wah, Oliver Stefan L

Abstract excerpt

Herpesviruses remain a burden for animal and human health, including the medically important varicella-zoster virus (VZV). Membrane fusion mediated by conserved core glycoproteins, the fusogen gB and the heterodimer gH-gL, enables herpesvirus cell entry. The ectodomain of gB orthologs has five domains and is proposed to transition from a prefusion to postfusion conformation but the functional relevance of the...

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Identifiers

PMID: 38042814
DOI: 10.1038/s41467-023-43011-w
PMCID: PMC10693595

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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