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Article

A surface pocket in the cytoplasmic domain of the herpes simplex virus fusogen gB controls membrane fusion

2022-03-14

Abstract excerpt

<h4>ABSTRACT</h4> Membrane fusion during the entry of herpesviruses is carried out by the viral fusogen gB that is activated by its partner protein gH. Unusually, the fusogenic activity of gB is controlled by its cytoplasmic (or intraviral) domain (gB CTD ) and, according to the current model, the gB CTD is a trimeric, inhibitory clamp that restrains gB in the prefusion conformation. But how the gB CTD clamp i...

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Literature Corpus work
43d8e96d-29ab-5666-be3b-3d78f2d4e662
DOI
10.1101/2022.03.14.484201
Open publication

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A surface pocket in the cytoplasmic domain of the herpes simplex virus fusogen gB controls membrane fusionDOI 10.1101/2022.03.14.484201
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