Functional dissection of HCMV gB's autonomous fusion activity provides insights into how polymorphisms in clinical isolates confer distinct characteristics.

Abstract excerpt

Glycoprotein B (gB) serves as the viral fusogen facilitating entry and cell-to-cell spread of human cytomegalovirus (HCMV). Fusion is initiated when gH/gL-containing complexes bind to their receptors, leading to gB's transition from a metastable prefusion to a stable postfusion conformation. We recently demonstrated that substituting or truncating the carboxy-terminal domain of gB renders it intrinsically...

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