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Article

The native conformational landscape and priming mechanism of herpes simplex virus glycoprotein B.

Science advances - 24 Jul 2026

Mou Zongjun, Wang Shanshan, Swanback Lauren, Pan Yong, Tsai Tiffany, Ji Peicheng, Su Jordan, Sahoo Bibekananda, Dai Xinghong

Abstract excerpt

Glycoprotein B (gB) of herpesviruses mediates membrane fusion with host cells during viral entry. Stabilizing gB in its prefusion conformation is a primary strategy for vaccine development. While prefusion-like gB structures of several human herpesviruses have been solved, the native conformational landscape and structural dynamics of gB remain largely unknown. Here, we report cryo-electron microscopy structures...

Topics

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Cryoelectron Microscopy
Herpesvirus 1, Human
Models, Molecular
Mutation
Protein Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viral Envelope Proteins

Virus Internalization

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Identifiers

PMID: 42497258
DOI: 10.1126/sciadv.aed8023
PMCID: PMC13398477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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