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Article

Dysregulated Glycoprotein B-Mediated Cell-Cell Fusion Disrupts Varicella-Zoster Virus and Host Gene Transcription during Infection.

Journal of virology - 1 Jan 2017

Oliver Stefan L, Yang Edward, Arvin Ann M

Abstract excerpt

The highly conserved herpesvirus glycoprotein complex gB/gH-gL mediates membrane fusion during virion entry and cell-cell fusion. Varicella-zoster virus (VZV) characteristically forms multinucleated cells, or syncytia, during the infection of human tissues, but little is known about this process. The cytoplasmic domain of VZV gB (gBcyt) has been implicated in cell-cell fusion regulation because a gB[Y881F]...

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Identifiers

PMID: 27795423
DOI: 10.1128/JVI.01613-16
PMCID: PMC5165202

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Source receipt: pubmed, retrieved 7 Sept 2026.

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