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Article

A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection

2020-12-23

Abstract excerpt

<h4>ABSTRACT</h4> Neutrophil responses against pathogens must be balanced between protection and immunopathology. Factors that determine these outcomes are not well-understood. In a mouse model of genital herpes simplex virus-2 (HSV-2) infection, which results in severe genital inflammation, antibody-mediated neutrophil depletion reduced disease. Comparative single cell RNA-sequencing analysis of vaginal cells ag...

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Identifiers and source

Literature Corpus work
6d02c63d-5d7f-5ccf-b27f-3ea485fefe7e
DOI
10.1101/2020.12.20.423690
Open publication

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A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infectionDOI 10.1101/2020.12.20.423690
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