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Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

28 Jun 2019

Abstract excerpt

Abstract Understanding how immune challenges elicit different responses is critical for diagnosing and deciphering immune regulation. Using a modular strategy to interpret the complex transcriptional host response in mouse models of infection and inflammation, we show a breadth of immune responses in the lung. Lung immune signatures are dominated by either IFN-γ and IFN-inducible, IL-17-induced neutrophil- or...

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PMID: 31253760
DOI: 10.1038/s41467-019-10601-6

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