Article

Uncovering the Neutrophil Inflammatory Response in Severe COVID-19: Implications of Type I Interferon in Inflammasome Activation

2023-09-12

Abstract excerpt

Background: The severity of COVID-19 is linked to excessive inflammation. Neutrophils represent a critical arm of the innate immune response and are major mediators of inflammation, but their role in COVID-19 pathophysiology remains poorly understood.<br><br>Methods: We conducted transcriptomic profiling of neutrophils obtained from patients with mild and severe COVID-19, as well as from SARS-CoV-2 infected mice,...

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Literature Corpus work: 94be5921-00fa-507b-8d05-42a4d08d9eee
DOI: 10.2139/ssrn.4564670

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