Article

Neutrophil NADPH oxidase breaks the inflammatory IL-1β/IL-17A circuit to enhance pathogen clearance during respiratory virus infections

2024-09-13

Abstract excerpt

<h4>Summary</h4> Respiratory virus infections are invariably accompanied by an increase in oxidative stress, characterised by elevated production of Reactive Oxygen Species (ROS) in the lung, which plays a pivotal role in both pathogenesis and host defence. Using a mouse model, neutrophil NADPH Oxidase 2 (Nox2) emerges as a key player, primarily responsible for generation of ROS during the early phases of Influen...

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Literature Corpus work: 7c97f9db-0021-5607-9ecf-14c7fef3131e
DOI: 10.1101/2024.09.12.612505

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