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A Review on CRISPR-mediated Epigenome Editing: A Future Directive for Therapeutic Management of Cancer

18 Jan 2022

Abstract excerpt

Recent studies have shed light on the role of epigenetic marks in certain diseases like cancer, type II diabetes mellitus (T2DM), obesity, and cardiovascular dysfunction, to name a few. Epigenetic marks like DNA methylation and histone acetylation are randomly altered in the disease state. It has been seen that methylation of DNA and histones can result in down-regulation of gene expression, whereas histone...

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PMID: 35078394
DOI: 10.2174/1389450123666220117105531

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