Article

AlleleAnalyzer: a tool for personalized and allele-specific sgRNA design

2018-06-08

Abstract excerpt

The CRISPR/Cas system is a highly specific genome editing tool capable of distinguishing alleles differing by even a single base pair. However, current tools only design sgRNAs for a reference genome, not taking into account individual variants which may generate, remove, or modify CRISPR/Cas sgRNA sites. This may cause mismatches between designed sgRNAs and the individual genome they are intended to target, leadi...

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Literature Corpus work: 4b7242cc-827e-5299-82ed-783791c55e03
DOI: 10.1101/342923

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