Article
Allele-Specific Epigenome Editing.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018
Bashtrykov Pavel, Jeltsch Albert
Abstract excerpt
The discovery and adaptation of the CRISPR/Cas system for epigenome editing has allowed for a straightforward design of targeting modules which can direct epigenetic editors to virtually any genomic site. This advancement in DNA-targeting technology brings allele-specific epigenome editing into reach, a "super-specific" variation of epigenome editing whose goal is an alteration of chromatin marks at only one...
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