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Article

Protocol for Allele-Specific Epigenome Editing Using CRISPR/dCas9.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2024

Rajaram Nivethika, Bashtrykov Pavel, Jeltsch Albert

Abstract excerpt

The discovery and adaptation of CRISPR/Cas systema for epigenome editing has allowed for a straightforward design of targeting modules that can direct epigenome editors to virtually any genomic site. This advancement in DNA-targeting technology brings allele-specific epigenome editing into reach, a "super-specific" variation of epigenome editing whose goal is an alteration of chromatin marks at only one selected...

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Source

Identifiers

PMID: 39012596
DOI: 10.1007/978-1-0716-4051-7_9

Genes

DNMT3A
NARF
PAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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