Article

Load-Dependent Effects of Sodium Glucose Co-Transporter Inhibitors on Work in Human Hypertrophic Cardiomyopathy Living Myocardial Slices

2025-12-07

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Disease modifying therapies for hypertrophic cardiomyopathy (HCM) remain a prevailing unmet need. Human-based experimental platforms capable of controlled manipulation of preload and afterload can distinguish direct myocardial and systemic effects and facilitate development of targeted cardiac therapeutics. Sodium glucose cotransporter inhibitors (SGLTi) may directly affect...

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Literature Corpus work: 6cb316ab-9208-562b-b2e2-4bd71aef516e
DOI: 10.64898/2025.12.03.692183

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