Article

Sex- and Exercise-Dependent Modulation of Hypertrophic Remodeling by the MCT1 rs1049434 Polymorphism

2025-12-30

Abstract excerpt

<h4>Background: </h4> The monocarboxylate transporter 1 (MCT1) plays a central role in myocardial lactate handling and metabolic adaptation. The functional rs1049434 polymorphism (T1470A; Asp490Glu) affects MCT1-mediated lactate transport and substrate utilization, but its clinical relevance in sarcomere-related hypertrophic cardiomyopathy (HCM) remains poorly defined. <h4>Methods:</h4> We studied 56 carriers of p...

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Literature Corpus work: 3638e8a7-43f7-50c9-b3e5-14ce9b852c21
DOI: 10.20944/preprints202512.2589.v1

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