Article

Hearts may grow concentrically to balance ATP supply and demand and eccentrically to stabilize titin-based stress

2026-05-13

Abstract excerpt

Hearts change their wall thickness (concentric growth) and chamber size (eccentric growth) as they adapt to circulatory demands and the intrinsic function of their contractile cells. Factors associated with wall thickening include variants of sarcomeric proteins that enhance contractility, mitochondrial dysfunction, and hypertension. Chambers can dilate due to many factors including sarcomeric variants that depres...

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Literature Corpus work: a01b7b03-0aae-501a-bdee-f585762e9679
DOI: 10.64898/2026.05.10.724147

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