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Article

Increased Myocardial Oxygen Consumption Precedes Contractile Dysfunction in Hypertrophic Cardiomyopathy Caused by Pathogenic TNNT2 Gene Variants.

Journal of the American Heart Association - 21 Apr 2020

Parbhudayal Rahana Y, Harms Hendrik J, Michels Michelle, van Rossum Albert C, Germans Tjeerd, van der Velden Jolanda

Abstract excerpt

Background Hypertrophic cardiomyopathy is caused by pathogenic sarcomere gene variants. Individuals with a thin-filament variant present with milder hypertrophy than carriers of thick-filament variants, although prognosis is poorer. Herein, we defined if decreased energetic status of the heart is an early pathomechanism in TNNT2 (troponin T gene) variant carriers. Methods and Results Fourteen individuals with...

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Identifiers

PMID: 32290750
DOI: 10.1161/JAHA.119.015316
PMCID: PMC7428531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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