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Myocardial testosterone glucuronide and disease phenotypes in hypertrophic cardiomyopathy.

ESC heart failure - 3 Feb 2026

Ikoma Takenori, Akita Keitaro, Ohno Kazuto, Satoh Terumori, Sato Ryota, Islam Ariful, Islam Md Monirul, Omagari Ryo, Komatsu Kazuyuki, Unno Kyoko, Iguchi Keisuke, Suwa Kenichiro, Sakamoto Atsushi, Kahyo Tomoaki, Takamisawa Itaru, Takayama Morimasa, Iwakura Tomohiro, Takanashi Shuichiro, Saitsu Hirotomo, Setou Mitsutoshi, Maekawa Yuichiro

Abstract excerpt

INTRODUCTION: The relationship between myocardial lipid metabolism and disease phenotypes, genetic variation, and prognostic factors in patients with hypertrophic cardiomyopathy (HCM) remains largely unexplored. This study aimed to clarify how metabolic remodelling relates to disease phenotypes in HCM. We used desorption electrospray ionization imaging mass spectrometry (DESI-IMS) to compare myocardial lipid...

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Identifiers

PMID: 41711723
DOI: 10.1093/eschf/xvag024
PMCID: PMC13108264

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