Article

Length-dependent hypercontractility decoupled from cellular adaptations is the initial phenotype in MYBPC3-haploinsufficient iPSC-derived engineered cardiac tissues

2026-05-15

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is often characterized by a complex landscape of secondary compensatory changes, making it difficult to distinguish primary events triggered by the underlying genetic variants. Here, using patient-derived iPSC-engineered heart tissues cultured in conditions minimizing external stimuli, we identify the initial phenotype of the HCM inducing variant MYBPC3-Q1061X. We demonstrate that...

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Literature Corpus work: 6d58d2c5-c8bb-52a9-99ec-c3ee440f2696
DOI: 10.64898/2026.05.13.724801

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