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Article

Angiotensin Type 1 Receptor Antagonists Protect Against Alpha-Synuclein-Induced Neuroinflammation and Dopaminergic Neuron Death.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics - 1 Oct 2018

Rodriguez-Perez Ana I, Sucunza Diego, Pedrosa Maria A, Garrido-Gil Pablo, Kulisevsky Jaime, Lanciego Jose L, Labandeira-Garcia Jose L

Abstract excerpt

The loss of dopaminergic neurons and α-synuclein accumulation are major hallmarks of Parkinson's disease (PD), and it has been suggested that a major mechanism of α-synuclein toxicity is microglial activation. The lack of animal models that properly reproduce PD, and particularly the underlying synucleinopathy, has hampered the clarification of PD mechanisms and the development of effective therapies. Here, we...

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Identifiers

PMID: 29987762
DOI: 10.1007/s13311-018-0646-z
PMCID: PMC6277291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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